Furthermore, in a study with nine polymorphism present in the PON gene cluster, Q192R; L55M; C-162T; rs705382(C > A/G); rs854548(A > C/G/T) and rs757158 (C > T) in PON1 gene, rs7493 (G > C) and rs11981433 (T > C,G) in PON2 gene and INS2+3651A > G in PON3 gene, in the Chinese population, no association was found between these SNPs and sporadic ALS [168]. This evidence concerns the gene PON2 and amyotrophic lateral sclerosis.