In particular, we showed that uL3ΔHCT 116p53−/− colon cancer cells in which uL3 levels were strongly lower than those in the parental cell line [17] resulted in being resistant to different chemotherapeutic agents including 5-FU, oxaliplatin, and actinomycin D [17,18,19,20]. The gene discussed is RPL3; the disease is colonic neoplasm.