To investigate the possibility that the results observed in SR-BI flox/flox/Tie2-Cre on the protective effects of HDLs in our model of ischemic stroke might be related, at least in part, to SR-BI deletion in myeloid cells, we generated SR-BI flox/flox/LysM-Cre mice to specifically inactivate SR-BI in the myeloid lineage. The gene discussed is SCARB1; the disease is ischemic stroke.