Biologics already play an important role in the treatment of disease, in areas such as diabetes (insulin, GLP-1) osteoporosis (sCT and PTH) and rheumatoid arthritis (TNF blockade) and treatment of these, and other chronic disorders, will soon be transformed by the advent of the up-coming methods described here for their delivery as oral medications. This evidence concerns the gene PTH and rheumatoid arthritis.