ROR2 and infection: Compared with uninfected cells, the infection of human EVTs (SGHPL-4 cell line) with the CMV laboratory strain AD169 significantly inhibited Wnt-5a-mediated trophoblast migration and significantly increased ROR2 receptor expression: this led to a significant reduction in Wnt5a-induced trophoblast migration, resulting in a reduction in trophoblast motility (suggesting that ROR2 plays a critical part in the effect of CMV on trophoblast migration) [16].