Consistent with this evidence, data obtained in ER-negative and GPER1-positive cancer types have indicated that the over-expression of miR-144, induced by E2 and G-1 through the GPER1/PI3K/Akt/ERK/Elk1 axis, lead to reduced levels of the tumor-suppressor Runt-related transcription factor-1 (Runx-1) and the consequent induction of cell cycle progression [9]. The gene discussed is ESR1; the disease is cancer.