In detail, once again, the crosstalk with stromal cells is able to sustain the abnormal viability of B-cells in B-ALL: a stromal cell-mediated antiapoptotic effect on B-ALL cells mediated by Notch 3 and Notch 4 or JAG1/2 and DLL1 in a synergistic manner was described [106]. This evidence concerns the gene NOTCH3 and precursor B-cell acute lymphoblastic leukemia.