The Cancer Genome Atlas (TCGA) (https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga), a landmark cancer genomics program, reported that Notch 3 mRNA is 14–15 times more expressed in Non-Hodgkin Lymphomas (NHL) lymphocytes compared to normal B-cells as well as the “Human Protein Atlas” which confirmed a medium-high expression of Notch 3 receptor in lymphoma tissue versus a low expression in healthy controls (https://www.proteinatlas.org/). This evidence concerns the gene NOTCH3 and non-Hodgkin lymphoma.