Previous studies in cancer models have reported that upregulated miR-200c-3p inhibits expression of SOX2 to suppress proliferation and migration in renal cell carcinoma [53], and miR-200c-3p has also been shown to suppress proliferative and migratory capacities of nephroblastoma cells by targeting fibroblast growth factor receptor substrate 2 [54]. This evidence concerns the gene FRS2 and hereditary clear cell renal cell carcinoma.