Increased HR followed by an incorrect adjustment of repolarization, with inhomogeneous prolongation of the action potential duration, can lead to the dispersion of ventricle repolarization and fatal arrhythmias [33]; the additional role of renin-angiotensin system activity in the magnitude of the adrenaline response to hypoglycemia could also be considered in subjects with T1D [34]. Here, REN is linked to type 1 diabetes mellitus.