INS and diabetes mellitus: However, the post hoc test for multiple comparisons using the Holm-Bonferroni method showed the increased LR rate in patients with diabetes mellitus as no significant (adjusted significance level p = 0.0083), but confirmed the significant changes of LR in concomitant medication with insulin (adjusted significance level p = 0.0038) and elevated CRP (adjustet significance level p = 0.0056).