Mean, maximum, minimum, and range of APTw intensities could not distinguish HGG with or without MGMT methylation (9 glioblastomas with MGMT promoter methylation vs. 2 HGGs (Glioblastoma Grade 4 = 1, Anaplastic Astrocytoma Grade 3 = 1 without MGMT methylation), 5 glioblastoma were excluded as MGMT analysis was not done), P-values > .05 for all APTw image intensity variables, or mathematically insufficient number for statistical analysis. Here, MGMT is linked to glioblastoma.