The 2 baseline moderators, BMI and eGDR, together explained 61% of the across-study variance in DKA risk (Table 2): Patients with overweight and with insulin resistance may be at increased risk of DKA because they are more prone to unrestricted FFA lipolysis from their increased triglyceride stores during the negative glucose balance and insulin dose down-titration induced by SGLT2i [75]. Here, INS is linked to Insulin resistance.