ATP13A2 and Kufor-Rakeb syndrome: Mutations in lysosomal P5 type ATPase cation transporter, ATP13A2 (encoded by PARK9), which cause autosomal recessive parkinsonism (Kufor–Rakeb syndrome), produce severe mitochondrial fragmentation and mtDNA lesions in fibroblasts, potentially due to cellular zinc dyshomeostasis (43, 44).