Gut could initiate complex hormonal responses to changes in the nutritional status by secreting peptides like ghrelin, cholecystokinin (CCK), glucagon-like peptide 1 (GLP-1), fibroblast growth factor 19 (FGF19), etc., and some of these gut signals have also been considered as important mediators in NAFLD development [103]. The gene discussed is CCK; the disease is metabolic dysfunction-associated steatotic liver disease.