AKT3 and intrahepatic cholangiocarcinoma: Although it has been reported that M2 macrophages may promote EMT partially by increasing the secretion of cytokines and activating the AKT3/PRAS40 signaling pathway in ICC in vitro [34], the molecular mechanisms of ICC malignancy are not completely clear, and with the lack of clinical evidence, very little is known regarding their role in ICC in vivo.