In our MGAS, we confirmed associations at multiple genes previously associated with AD, such as APOE (p = 2.77E-08, rs769449), TOMM40 (p = 3.49E-08, rs769449), APOC1 (p = 1.18E-06, rs4420638), as well as identified a few novel associations shown in Table 4. This evidence concerns the gene APOE and Alzheimer disease.