APOE and Alzheimer disease: CM3 (Score = 4.37, p = 1.24E-05) contains 6 genes, including KEGG AD genes APOE APP, and CASP3. CM4 (Score = 4.32, p = 1.56E-05) contains 5 genes, including KEGG AD genes APOE, APP, and CASP3. CM5 (Score = 1.89, p = 5.88E-02) contains 6 genes with a marginal significance.