PLCG1 and hepatocellular carcinoma: IP3 could activate inositol 1, 4, 5‐triphosphate receptor (IP3R) to positively or negatively regulate autophagy12, 13; DAG production is necessary for efficient autophagy of Salmonella14; our previous study showed that inhibition of PLCγ1 induced autophagy in colon and hepatic carcinoma cells.15