For example, Zili et al found that HuR promoted autophagy via Beclin 1 26; Viiri et al also found that HuR relieved macular degeneration by activating autophagy via p62 40; and Li et al found HuR modulated autophagy to defence against invasive pathogens in the intestinal epithelium via Atg16L1.41 This evidence concerns the gene ATG16L1 and macular degeneration.