Of particular note were FN1 and FAM20A, identified to directly interact with AFP and to be part of the pathways “regulation of IGF transport and uptake by IGFBPs” and “post-translational protein phosphorylation” or “extracellular matrix organization.” It has been reported that IGF expression is associated with HCC development [46–48]. This evidence concerns the gene FAM20A and hepatocellular carcinoma.