PTEN and early-onset autosomal dominant Alzheimer disease: Indeed, PTEN is associated with 9 traits (Crohn's disease [22], Inflammatory bowel disease [23], Rheumatoid arthritis [24], Systemic lupus erythematosus [25], Ulcerative colitis [23], Coronary artery disease [26], Type 2 diabetes [27], Alzheimer's disease [28], Autism [29]) out of our analyzed 43 traits.