IFNG and TGFB1 for ccRCC (both of them regulated 36% significantly altered pathways of ccRCC), SPP1, HDAC1 and CUX1 (all of them regulated 9% significantly altered pathways of PRCC) for PRCC, and STAT3, RB1, NUPR1 and MECP2 (all of them regulated 8% significantly altered pathways of ChRCC) for ChRCC. The gene discussed is NUPR1; the disease is chromophobe renal cell carcinoma.