A study showed that the extracellular matrix protein (ECM) in serum and tissue of patients with GC regulates the metastasis of GC cell and metabolism of glucose through ITGB4/FAK/SOX2/HIF-1α signaling process induced by ECM receptor interaction, which is of great significance for the development of therapeutic targets for the prevention of tumor metastasis and recurrence [26]. This evidence concerns the gene ITGB4 and neoplasm.