Recent data illuminate this through single cell RNA sequencing of primary HSPCs from FA patients that showed overexpression of the MYC oncogene occurs in a subset of FA HSPCs and appears to be a counteracting force against the growth suppressive activities of TGFβ and p53, since inhibition of MYC expression reduces the proliferative capacity of FA HSPCs. This evidence concerns the gene TGFB1 and Friedreich ataxia.