CD8A and urothelial carcinoma: Finally, we speculate that LTag-targeted CD8 T-cell responses including those directed against the N-terminus shared with small T-antigen [37] may protect against BKPyV-associated urothelial carcinoma expressing solely LTag or truncated derivatives from chromosomally integrated BKPyV genomes [8,9], when there is little or no Vp1 expression [7].