Interestingly, when combined with infusion of GD2 antigen-directed CAR-T cells, NKG2D.ζ NK cells not only enhanced the recruitment of GD2 CAR-T cells to MDSC-containing tumor xenografts, but also improved GD2 CAR-T cell infiltration and anti-tumor activity after NK elimination of intra-tumoral MDSCs. The gene discussed is KLRK1; the disease is neoplasm.