This study also revealed that aberrant K-RAS is implicated in glucose metabolism intermediates channelling into different anabolic pathways, such as the hexosamine biosynthesis pathway (HBP) and pentose phosphate pathway (PPP), thus proving that glucose metabolism is necessary to fuel anabolic branches of PDAC metabolism to provide the cancer cells with building blocks for its increased proliferation demands [58]. Here, KRAS is linked to cancer.