The investigated mutation rSNP rs35126805 disrupts the metabolic pathway HNF-4α/HNF-1α by changing the electrostatic interactions between the HNF-4α transcription factor and the DNA causing MODY3 and potentially also hepatocellular carcinoma metastasis, as well as enhanced apoptosis in pancreatic cancer cells. Here, HNF4A is linked to familial pancreatic carcinoma.