The investigated mutation rSNP rs35126805 disrupts the metabolic pathway HNF-4α/HNF-1α by changing the electrostatic interactions between the HNF-4α transcription factor and the DNA causing MODY3 and potentially also hepatocellular carcinoma metastasis, as well as enhanced apoptosis in pancreatic cancer cells. This evidence concerns the gene HNF1A and familial pancreatic carcinoma.