Myricanol (4) also decreased tumor growth in xenografted BALB/c nude mice at a dosage of 40 mg/kg, by activating the expression levels of pro-apoptotic factors within the tumor cells and downregulating the protein expression of Bcl-2, VEGF, HIF-1α, and survivin, thus increasing the apoptotic rate of tumor cells [72]. The gene discussed is HIF1A; the disease is neoplasm.