This pS675 form might be stabilized by CCT and enters into cell nuclei to overexpress EMT markers, such as zinc-finger-containing Snail family members, Slug, Snail, and basic helix-loop-helix (bHLH) factor, and Twist, which are transcription factors that upregulate the expression of tumor suppressors. The gene discussed is SNAI2; the disease is neoplasm.