Specifically, after LINC00518 transient silencing, we observed reduced levels of LINGO2, NFIA, OTUD7B, SEC22C, and VAMP3 mRNAs, previously reported as oncogenes in several cancer models and targeted by tumor suppressive miRNAs potentially sponged by LINC00518. We also proposed that the direct binding of LINC00518 to the 3′-UTR of these mRNAs may prevent miRNA-mediated negative regulation. This evidence concerns the gene LINGO2 and cancer.