Nonetheless, leptin/OBR-induced upregulation of PAI-1 is much close to clinical situations than IL-6/GP130 in breast cancer, as the correlation between PAI-1 and OBR (r = 0.379) is much stronger than that between PAI-1 and GP130 (r = 0.064) and between PAI-1 and IL6R (r = 0.162) based on TCGA dataset (Table S6). Here, IL6 is linked to breast cancer.