PAI-1, as a target of miR-34a, has been verified in non-small-cell lung cancer (NSCLC) cells by luciferase reporter assays, while overexpression of miR-34a reduced PAI-1 expression at the protein but not mRNA level in A549 and H520 cells [39]. The gene discussed is SERPINE1; the disease is non-small cell lung carcinoma.