TP53 and pancreatic neoplasm: One example is AG490, a JAK2/STAT3 inhibitor, which could support the p53–p21 axis to induce Kaposi’s sarcoma-associated herpesvirus (KSHV) lytic cycle activation in lymphoma cells or downregulate HSP90 as well as mtp53 expression in glioblastoma and pancreatic cancer cells [160,162].