Indeed, the endothelial cell P2Y1 receptor strongly contributes to leukocyte recruitment and exposure of adhesion molecules (P-selectin, ICAM-1, and VCAM-1) during inflammation [115], and P2Y1−/−/ApoE−/− mice showed reduced macrophage infiltration and atherosclerosis lesions [116]. Here, APOE is linked to atherosclerosis.