In the context of BC, it was shown that HMLER-derived CSC-like cells were resistant to γδ T cell-mediated killing; however, the inhibition of the farnesyl pyrophosphate synthase induced the upregulation of both MHC class I and CD54/ICAM-1, and consequently increased the susceptibility to γδ T and CD8+ T cell-mediated lysis [115]. Here, ICAM1 is linked to breast cancer.