A considerable number of primary publications have reported the differential TMEFF2 methylation when compared to adjacent normal tissue or the corresponding tissue from healthy individuals in a variety of cancers including breast [27,28,29,30,31,32], prostate [3,31], lung [8,25,28,31], bladder [3], colon and rectal [3,8,10,24,28,32,33,34], gallbladder [35], renal [36], oesophageal [37,38], cardiac [37], stomach/gastric [10,37,39], ovarian [8], multiple myeloma [31], glioblastoma [8] and mesothelioma [40]. This evidence concerns the gene TMEFF2 and glioblastoma.