FH and age-related macular degeneration: With the expression of the Y402H allele, the binding of the FH Y402H to GAGs in Bruch’s membrane is impaired [45,67,88,89], which leaves some individuals more prone to AMD — e.g., deposited MAC is found to be increased by >60% in the choroids of 402H homozygous individuals compared to 402Y homozygous individuals [43].