In addition, salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L, down-regulates the mRNA expression level of LOX, LOXL1-4, and HIF-1α in a dose-dependent manner in pancreatic cancer cells [101]; thereby, the invasive activity of cancer cells, xenograft tumor growth, and distal metastasis can be hindered by treatment with salidroside [101]. The gene discussed is LOX; the disease is cancer.