LOXL2 and hepatocellular carcinoma: More specifically, Wong et al. found that miR-29a-3p and miR-26a-5p bind to the 3′untranslated region (3′UTR) of LOXL2 mRNA, leading to suppression of LOXL2 expression, which is essential for the promotion of TME and the formation of a pre-metastatic niche in HCC [42].