DNA demethylation small molecule 5-aza-CR exhibits a suppressive effect on tumor growth and cell proliferation by triggering the LOXL4-p53 signaling pathway to activate the expression of pro-apoptotic genes, p53 inducible gene 3 (PIG3) and Bcl-2-associated X protein (BAX) [58]. This evidence concerns the gene LOXL4 and neoplasm.