LOXL4 and hepatocellular carcinoma: With reference to the epigenetic episode, Shao et al. demonstrated that 5-azacytidine (5-aza-CR), acting on hypomethylation of DNA by inhibiting DNA methyltransferase, induces LOXL4 upregulation and triggers LOXL4-depedent cell apoptosis in HCC [58].