The mechanism accounting for the 5-azacytidine-induced LOXL4-p53 axis of HCC cells lies in the binding between D677/D679 in LOXL4 and K381/382 in p53, noted to occur in other cancer types, including lung, breast, and ovarian cancers, as well as melanoma [58]. The gene discussed is LOXL4; the disease is melanoma.