CRP and type 2 diabetes mellitus: In patients with Type 2 diabetes mellitus (T2DM) studied using a hyperinsulinemic hypoglycemic clamp, mild hypoglycemia (2.7 mM) induces the production of markers of oxidative stress and inflammation including c-reactive protein and urinary free 8-isoprostoglandin F2α (8-iso PGF2α) [35].