CRP and type 2 diabetes mellitus: One large-scale study of over 11,000 older patients observed no relationships between HbA1C, variability in HbA1C, c-reactive protein levels, and cognitive performance [93]; however, several other studies amongst healthy, older patients with T2DM and no history of cognitive dysfunction found that long-term GV was associated with lower metrics of cognitive function [90,91] as well as with decreased levels of limbic and temporal–parietal gray matter [92].