We found a high agreement on treatment of MDS del(5q) patients with LEN (39/40, 97.5%), agreement on treatment with LEN of patients with one or two additional cytogenetic alteration except chromosome 7 (29/38, 76.3%) and agreement on assessment of TP53 mutational status before LEN start (25/38, 65.8%) and in LEN non-responders (24/38, 63.2%). The gene discussed is TP53; the disease is myelodysplastic syndrome.