Furthermore, NK cells, like CD8+ T cells, act against the tumour by inducing pro-apoptotic and pro-inflammatory factors such as TNF-α, IL-6, IFN-γ and granulocyte-macrophage colony-stimulating factor (GM-CSF) in an attempt to induce proliferation and differentiation of hematopoietic cells [114]. This evidence concerns the gene CSF2 and neoplasm.