Several of the recurrently detected genetic abnormalities in patients with myeloid malignancies involve epigenetic modifiers like DNMT3A, TET2, ASXL1, EZH2, IDH1/2, KMT2A, KAT6A, KDM5A, KDM6A, or NSD1 [71,72,73,74]. The gene discussed is KMT2A; the disease is myeloid neoplasm.