Of note, other subtypes of leukemia that show a high dependency on wild-type MLL1, like NPM1-, DNMT3A-, and IDH1/2-mutated as well as NUP98-rearranged AML, have been shown to be likewise sensitive to inhibition of DOT1L [153,168,169,170,171]. The gene discussed is KMT2A; the disease is acute myeloid leukemia.