These models were similar to their human cancer counterpart (Figure S1) but were highly diverse in their genomic and proteomic profiles, TNBCtype, and with a wide range of PI3K pathway activities, as indicated by the RPPA PI3K activity score and levels of phosphorylated AKT, S6K, and PTEN expressions (Figure 1, Table 1). The gene discussed is PIK3CA; the disease is cancer.