Angiotensin-converting enzyme 2 (ACE II), highly expressed in lung alveolar type 2 cells, is also present in multiple tissues, including heart, kidneys and cerebrovascular endothelial cells.[30,31,32] Therefore, it would be rational to suggest that ACE II could be involved in COVID-19 neurovascular infection, leading to autoregulation disruption and episodes of high blood pressure spikes, which could result in arterial wall rupture and SHA or ICH. This evidence concerns the gene ACE2 and COVID-19.