REN and polycystic ovary syndrome: Drospirenone can resist mineralocorticoids, antagonize the RAS system, reduce the levels of renin and angiotensin, and improve the state of hyperandrogenemia; ethinyl estradiol cyproterone tablets are the third-generation oral contraceptives, each containing cyproterone 2 mg and ethinyl estradiol 0.035 mg.[22–23] Containing cyproterone is a synthetic progesterone with high progesterone activity derived from 17-hydroxyprogesterone.