So far, the best way to prevent PSD is to prevent stroke recurrence and severity by using optimal acute treatment and intensive secondary prevention.[11] Cholinesterase inhibitors commonly used in Alzheimer disease (AD), such as donepezil, also have positive effects on PSCI patience.[12–14] However, the uncertainty on the global and daily function makes it difficult to evaluate the worth of the drugs on clinic.[15] Therefore, it is of vital importance to explore effectively treatment to slow or stop disease progression. This evidence concerns the gene BCHE and Alzheimer disease.