CD4 and myasthenia gravis: The pathogenesis of MG still remains completely unclear, but imbalance in immune regulation is considered to be a major contributor.[2] Recent studies have shown that immune cells, especially regular T cells (Treg), play an important role in the pathogenesis and progression of MG, and CD4+CD25+Treg phenotypes and functional defects may also be related to its pathogenesis.[3,4] The deletion of self-reactive T cells is responsible for the development of central tolerance in the thymus, where T cells mature.