Temozolomide (TMZ) is an active drug molecule and is used for the treatment of patients having gliomas and O6-methylgaunine-DNA-methyltransferase (MGMT) promoter methylation is an independent prognostic factor.[9] Besides, TMZ combination with olaparib has also achieved good results in the treatment of small cell lung cancer patients. Here, MGMT is linked to central nervous system cancer.