MKI67 and cancer: Its function is closely related to mitosis and it is an indispensable component for cell proliferation.[49] As one of the most widely used cell proliferation markers, Ki-67, can reflect the degree of malignant cell proliferation and is closely related to the progress, metastasis, and prognosis of various malignant tumors.[50] When tracing the display of Ki-67 throughout the cell cycle, there is no expression in GO, an initial appearance in G1, increases in the S and G2 phases, maximal levels in the M phase, and a rapid dissipation in the late stage of cell division.