STAT3 and cancer: Huanglian Jiedu Decoction is one of the important intervention methods for these diseases in China.[13–15] Besides, some reports about mechanism of Huanglian Jiedu Decoction have revealed its multichannel, which includes JAK2/STAT3, TLR4/MyD88 signaling pathway, etc, anti-inflammatory, and anti-cancer effect.[11,21–23] After careful literature search, we found there is no quantitative meta-analysis on the treatment of MM by Huanglian Jiedu Decoction so far.