Moreover, in keeping with reduced progenitors including megakaryocyte-erythroid progenitors (MEPs), the functional capacity of mutant bone marrow to produce BFU-E and CFU-E colonies in vitro is strikingly reduced (Fig 5E), all of which would be predicted to contribute to pancytopenia in the absence of RASA3. The gene discussed is RASA3; the disease is Pancytopenia.